Radiation-Induced Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia
نویسندگان
چکیده
منابع مشابه
Radiation-Induced Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia
Tumor lysis syndrome (TLS) is an important oncological emergency that is usually observed with hematological malignancies and rarely with solid tumors. It can be induced either by therapy or spontaneously. Radiotherapy-induced TLS has been rarely reported in the literature. Here we present a patient with a diagnosis of metastatic prostate cancer and chronic lymphocytic leukemia complicated with...
متن کاملA pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.
PURPOSE Flavopiridol, the first clinically evaluated cyclin-dependent kinase inhibitor, shows activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this study was to investigate the relationships between pretreatment risk factors, drug pharmacokinetics, and ...
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mAb (eculizumab), investigators also used an ELISA that measured C5a/C5a(desArg). Regardless, we suspect that eculizumab blocks generation of C5a in sensitized red cell assays (ex vivo) but may not prevent enzymatic generation of C5a in vivo. Although C5 blockade has proven efficacious in a variety of clinical disorders, further research is warranted to assess the potential benefits or harms of...
متن کاملTumor lysis syndrome and acute anemia in an African-American man with chronic lymphocytic leukemia
Tumor lysis syndrome (TLS) is a life-threating hematologic emergency caused by massive lysis of tumor cells into the blood stream. TLS can be prevented and treated with rasburicase. Rasburicase-induced hemolysis and methemoglobinemia is a rare but serious complication. Screening for G6PD should be considered for patients at higher risk for G6PD deficiency who may be also at high risk for TLS on...
متن کاملCancer Therapy: Clinical APharmacokinetic/PharmacodynamicModel of Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia Patients Treated with Flavopiridol
Purpose: Flavopiridol, the first clinically evaluated cyclin-dependent kinase inhibitor, shows activity in patients with refractory chronic lymphocytic leukemia, but prevalent and unpredictable tumor lysis syndrome (TLS) presents a major barrier to its broad clinical use. The purpose of this study was to investigate the relationships between pretreatment risk factors, drug pharmacokinetics, and...
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ژورنال
عنوان ژورنال: Turkish Journal of Hematology
سال: 2016
ISSN: 1300-7777
DOI: 10.4274/tjh.2015.0259